.....An increased level of circulating cytokines originating in - TopicsExpress

.....An increased level of circulating cytokines originating in the connective system, due to systemic pathologies, could develop neuropathic pain.43–46 The connective tissue can directly convey pain signals; in fact, it contains nociceptors that can translate mechanical stimuli into pain information. Furthermore, if there are nonphysiological mechanical stimuli, the proprioceptors can turn into nociceptors.3,6,7..... Bordoni B, Zanier E. Clinical and symptomatological reflections: the fascial system. Journal of Multidisciplinary Healthcare 2014:7 401–411

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