[DOI: 10.2174/1874091X01206010040] Hypothetical Two-Step - TopicsExpress

[DOI: 10.2174/1874091X01206010040] Hypothetical Two-Step Initiation of Experimental Carcinogenesis by Polycyclic Aromatic Hydrocarbons and Aminoazo Dyes, 2012; 6: Pp 40-42 Bodo Contag Published Date: (27 April, 2012) A new hypothesis is discussed, which describes the initiation of the carcinogenesis through polycyclic aromatic hydrocarbons (PAHs) and aminoazo dyes (AZOs) as a two-step process: the oncogenic proteins of the ras or ras-like on-cogenes activated by mutation ("initiation A ") co-operate with the complexes in the plasma membrane formed during the "initiation B " stage from the parent compounds of the PAHs or AZOs with cholesterol and apolipoprotein A-I. The final result of this co-operation, or the "complete initiation", is an irreversibly modified membrane architecture with negative consequences for growth control. benthamscience/open/tobiocj/articles/V006/40TOBIOCJ.pdf

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