(The problem in preventing Sirt1 deactivation by NO is that its - TopicsExpress

(The problem in preventing Sirt1 deactivation by NO is that its probably a feedback mechanism as Sirt1 also activates eNOS) Cellular experiments revealed that S-nitrosylation inactivates SIRT1 by interfering with the proteins ability to bind zinc, which in turn increases the activation of p53 and of a protein subunit of NF-kappaB. Experiments in mouse models of systemic inflammation, age-related muscle atrophy and Parkinsons disease found that blocking or knocking out NO synthase - the enzyme that induces nitric oxide generation - prevented the cellular and in the Parkinsons model behavioral effects of the diseases. Additional experiments pinpointed the S-nitrosylation of SIRT1 as a critical point in the chain of events leading from nitric oxide expression to cellular damage and death.medicalxpress/news/2014-11-molecular-contribute-major-aging-related-diseases.html?utm_content=bufferab775&utm_medium=social&utm_source=facebook&utm_campaign=buffer

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