#المختبرالطبي_التخصصي #أبحاث_Research #New_Study Now researchers from France believe they found a genetic mechanism that caused two HIV-infected patients to be “spontaneously” cured. The two cured men, one who has been HIV positive for 30 years and the other for five, never contracted AIDS from the virus, and now, even though HIV cells are still in their bodies, the disease is completely dormant. In essence, the men’s bodies turned the disease off, which researchers believe was possible because of a genetic mutation that regulates the disease’s replication. Now, after sequencing the genome of the two “elite controllers,” researchers believe this random genetic off-switch is triggered by the increased activity of the enzyme APOBEC. Understanding what enzyme is needed to turn the virus off will hopefully lead to better ways to treat the disease. If researchers can figure out how to stimulate APOBEC in other patients, we may even see a viable HIV cure in the future. Source: modernnotion/mutation-brings-hiv-cure-closer/ Research Published in Clinical Microbiology and Infection (onlinelibrary.wiley/doi/10.1111/1469-0691.12807/abstract)
Posted on: Thu, 06 Nov 2014 19:27:50 +0000
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