A DELETION involves loss of a part (a segment) of a chromosome and is sometimes known as a PARTIAL MONOSOMY. Deletions can occur in any part of any chromosome. If the segment is lost from near to the centromere, this is called a PROXIMAL DELETION. If the segment is lost from nearer to the end of the chromosome (the telomere), then the deletion is called a DISTAL DELETION. If there is just one break in the chromosome, then the deletion is called a TERMINAL DELETION. (Terminal just refers to the end of the chromosome and does not infer that the deletion will be lethal to the child.) If there are two breaks in the arm of the chromosome with the intervening segment being lost and the remaining parts of the chromosome joining up, then this is called an INTERSTITIAL DELETION. Some deletions are particularly small and are called MICRODELETIONS.
Posted on: Sat, 28 Sep 2013 05:15:01 +0000
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