Acetaminophen is widely used as an analgesic and also lowers fever. Because it acts peripherally to alleviate pain and does not cross the blood-brain barrier, it is often used in combination analgesics containing opioids for pain related to acute injuries, postoperative pain, or pain after dental procedures. Acetaminophen is also commonly used as an over-the-counter (OTC) remedy for pain and fever medication, and it is often combined with medications to combat cough and cold symptoms or with other ingredients. However, excessive use of acetaminophen may result in severe liver damage. Study Synopsis and Perspective The US Food and Drug Administration (FDA) is asking healthcare professionals to stop prescribing combination prescription pain relievers that contain more than 325 mg of acetaminophen per tablet, capsule, or other dosage unit, citing the risk for liver damage. The action targets prescription analgesics that contain both acetaminophen and another ingredient, typically opioids such as codeine, oxycodone, and hydrocodone. Some of these combination products now have as much as 750 mg of acetaminophen per dose. In a statement, the FDA said, There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury.
Posted on: Mon, 10 Mar 2014 17:21:19 +0000