After, my appointment with Dr. Nigel Clarke at Concord Hospital, on Wednesday 28/ 08/13, and him saying that the results from Boston, show that my muscle myopathy a form of muscular dystrophy is due to a mutation in the TIN gene (titin protein). I came home and looked up my research that I did some years ago, on Congenital Myasthenia Gravis, which i thought I had and did at the time ask Dr N. Clarke and Professor Corbett if it was a possibility that i could have congenital myasthenia Gravis and they both said No, I dont have congenital Myasthenia Gravis. But, now them getting my exome sequencing results from Boston that shows my muscle myopathy that resulted in my muscle strength weakness is due to an autosomal recessive gene or a mutation not hereditary and is probably due to a mutation in the TIN (titin protein). I looked up my research notes again that i did a few years ago on Congenital Myasthenia Gravis ) thymoma, that i would like to share with world, to help me cure as no one wand if you could let me know what you think, Congenital Myasthenia Gravis (Thymoma) T- cell mediated pathogenesis, due to thymic abnormalities ( thymoma) The SEPN1 gene is on chromosome one. Selenoprotein N (a glycoprotein) localized in the endoplasmic reticulum belongs to a family of proteins mediating the affect of selenium and involved in various anti-oxidation defense systems and several metabolic pathways. A fault in the calcium-binding motif within the selenoprotein N, affecting intracellular calcium, in the pathogenesis of the core formation in fibres. Recessive SEPN1, a glycoprotein mutation that overlaps with the milder end of congenital muscular dystrophy spectrum suggested by observation of an increase in fat and connective tissue and whorled fibres, affected Type I fibres (scattered fibres and numerous cores and small myofibres with internal nemaline rods), where there are numerous cores on muscle biopsy an additional feature in patients with primary cardiomyopathy due to a mutation in TIN (titin protein) and since for me you say the results confirm it is the titin protein. Screening of muscle-derived cDNA, especially for an affected child inheriting a mutation from unaffected parents, mutation can only be TIN (titin protein). I will continue my argument of trying to prove it is Congenital myasthenia Gravis (thymoma) (blood test: No anti-ACHR or positive for MuSk antibodies), where blood serum contains antibodies that bind to skeletal muscles and heart muscles. These antibodies react with epitopes on the muscle protein (titin), This is due to maternal antibodies (Rh negative, my mother) that target the infants, me (Rh positive) acetylcholine receptors. I did a Laverty pathology blood test (serology study) for ACR antibody (20/05/10), i was still under my married name Hiam kristina Saadeh, and the result was a) ACR negative for acetylcholine receptor antibody, b) STR, anti-striated muscle antibodies, skeletal muscle antibodies less than 50 titre. MuSk (muscle specific tyrosine kinase, it seems to be important at the neuromuscular junction) c) Antibodies against Titin protein, ? have not been tested As a portion of patients without antibodies against ACHR, have antibodies against MuSk protein, which adds to the proof that it is congenital Myasthenia Gravis (thymoma) Also CT scan can be used to identify if Thymoma Congenital ptosis occurs through autosomal dominant mutation by a) Third cranial nerve palsy (from trauma) signs of aberrant regeneration are usually present. b) The pupils may be small and nonreactive. Congenital Myasthenia Gravis (T-cell mediated pathogenesis), where the thymus is the organ in the T-cell mediated immunity, resulting in thymic abnormalities (thymoma) My mother (Rh negative), injected with anti- D gamma globulin, after first child my older sister of five years. She had a miscarriage in between, but was not given booster injection, then five years later i was born, blood type (A positve), where survival rate of babies is 70% and only if blood type A or B. Where, Red blood cells (RBC) and anti-D globin antibodies, placental transfer into the babys (mine) blood attacks all globulin proteins; i.e. a) In the blood (due to attacking Hemoglobin) Slight anemia, alpha thalassemia or haemolytic anemia blood histology shows RBC die very young, and Vit B12 insufficiently absorbed b) In Skeletal muscles (due to attacking myoglobin) Degenerative muscle cells i.e. faulty muscle cells due to attacking Myoglobulin in muscle cells, resulting in less than 20% normal muscle cell formation. In summary, it is muscular dystrophy (muscle death), due to cranial nerve damage that is curable, but the evil man has gone ahead and used my research to further damage my cranial nerves by placing the business phone links that are radiation emitters and absorbers to cause the further damage in my cranial nerves to destroy all remaining muscles in my my body, where also my children who were born normal with no inherited muscle condition that he has placed the phone links with gamma emitting capacitance units the they use in robotic toys and never in humans to destroy their cranial nerves and to give them muscular dystrophy, and my ex husband, on top the effects of radiation sickness, which is bone crushing to powder and premature skin ageing, in skin elasticity loss, where our beauty was destroyed by in- house threading. to take us to the grave internally without anyone knowing. Where the evil man uses the business phone link without our knowledge or consent where, we are moved around in several hypnotic states 24/7, the phone battery and a speech converter that are placed in our throats attached to our hyoid jaw to convert their voices as us, where everything on the inside and outside is them, never us, unless they untrap us to rape our superior genius intelligence or our verbal skills in the power of Goodness, and then they trap us again in real life to exist as docile people with limited intelligence. and where temporal lobe sensors, occipital lobe sensors and frontal lobe sensors are placed in us to have total control. Temporal lobe to control our thoughts (like the feeling when you say, stop putting thoughts into my head,except it is thoughts forced into your head without permission or saying I must be suffering alzheimers, what did I just say, etc. by them trapping your temporal lobe and causing loss of short term memory recall , emotions, i.e. stimulation of temporal by induced electrical firing to cause instant rage with no hormonal precursor that is the normal human pattern needed,to bring on rage, that the evil man calls bipolar when such a condition doesnt exist), also to control our speech ( that is amplified by threading down of the tongue, where you are made to stutter, to have a lisp and to limit ability to correctly be able to pronounce words and read with fluency, that the evil man calls dyslexia, where such a condition doesnt exist).The electrical stimulation of the occipital lobe by controlling the sensitivity of the eye to light, to stimulate retinal rods cells, that are sensitive detectors to light ( rhodopsin, a photoreceptor glycoprotein of rods), synthesized by ribosomes that are attached to the endoplasmic reticulum, in transducing light into a nerve signal in the eye to control permeability of acteylcholine receptors to sodium ions by the enzyme aceytylcholinesterase, where calcium ions are the transmitter in the visual excitation of a photolized rhodopsin. A fault in the calcium-binding motif affecting intracellular calcium levels, leads to the decrease in the number of functional acetylcholine receptors which leads to defective neuromuscular transmission resulting in several diseases, like the eye disease glaucoma, blindness, and muscle weakness and fatigability, that can lead to in the respiratory chain to respiratory paralysis, and lead to failure of organs, like, liver failure and other metabolic diseases. In congenital myasthenia Gravis, a humans own antibodies attack their own acetylcholine receptors.an autoimmune disorder. That can be brought on in vitro by electrical stimulation of the acetylcholine receptors that is electrically controlled release form of secretion to bring on all the above diseases, by control eye movement, and amount of light entering the eye and the type of light intensity. The frontal lobe to control motor skills, like being clumsy or tripping over your own feet. Please SOS, to the world.and that is what it is for me Kristina touma the mother of louis and stephanie saadeh with a heartfelt mindset
Posted on: Sat, 26 Oct 2013 03:06:02 +0000
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