Alpha 1-Antitrypsin deficiency Decreased levels of a1-antitrypsin - TopicsExpress

Alpha 1-Antitrypsin deficiency Decreased levels of a1-antitrypsin can lead to lung emphysema or liver cirrhosis. CAUSE : Alpha 1-Antitrypsin is a liver-derived protein which acts as an inhibitor of tissue proteases, in particular neutrophil elastase. Levels of a1-antitrypsin results in increased elastase activity. In the lung, there is increased breakdown of elastin and decreased mucociliary clearance leading to emphysema and chronic bronchitis.Alpha 1-Antitrypsin accumulation in hepatocytes appears to be responsible for liver damage, but the mechanism is unclear.

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