Also other drug metabolising enzyme rather than phase one type (I.e CYP450) is phase two type(such as NAT, GST, UGT, etc) are being genetically polymorphic n in turn may play a role in ADR. Both phase I and II drug metabolisms may involve in the activation and elimination of any drug from the body. However, one of the benefits of completing the human genome is to study the allelic variants of these enzymes.
Posted on: Mon, 02 Sep 2013 11:25:04 +0000
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