Altered TGF-β Expression in FMD - FASEB - April 2014 Clinical - TopicsExpress

Altered TGF-β Expression in FMD - FASEB - April 2014 Clinical and biochemical profiles suggest fibromuscular dysplasia is a systemic disease with altered TGF-β expression and connective tissue features. S.K. Ganesh, R. Morisette, Z. Xu, F. Schoenhoff, B.F. Griswold, J. Yang, L. Tong, M. Yang, K. Hunker, L. Sloper, S. Kuo, R. Raza, D.M. Milewicz, C.A. Francomano, H.C. Dietz, J. Van Eyk, N.B. McDonnell. Abstract: Fibromuscular dysplasia (FMD) is a rare, nonatherosclerotic arterial disease for which the molecular basis is unknown. We comprehensively studied 47 subjects with FMD, including physical examination, spine magnetic resonance imaging, bone densitometry, and brain magnetic resonance angiography. Inflammatory biomarkers in plasma and transforming growth factor β (TGF-β) cytokines in patient-derived dermal fibroblasts were measured by ELISA. Arterial pathology other than medial fibrodysplasia with multifocal stenosis included cerebral aneurysm, found in 12.8% of subjects. Extra-arterial pathology included low bone density (P

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