Angina pectoris in patients with heart failure with preserved ejection fraction is independently associated with increased major adverse cardiac events due to revascularization with similar risk of death, MI, and hospitalization. In the Duke Databank, 3,517 patients met criteria for inclusion and 1,402 (40%) had angina pectoris (AP). Those with AP were older with more comorbidities and prior revascularization compared with non-AP patients. AP patients more often received beta-blockers, angiotensin-converting enzyme inhibitors, nitrates, and statins (all p < 0.05). In unadjusted analysis, AP patients had increased MACE and death/MI/revascularization (both p < 0.001), lower rates of death and death/MI (both p < 0.05), and similar rates of death/MI/stroke and cardiovascular death/cardiovascular hospitalization (both p > 0.1). After multivariable adjustment, those with AP remained at increased risk for MACE (hazard ratio [HR]: 1.30, 95% confidence interval [CI]: 1.17 to 1.45) and death/MI/revascularization (HR: 1.29, 95% CI: 1.15 to 1.43), but they were at similar risk for other endpoints (p > 0.06). Robert J. Mentz. J Am Coll Cardiol. 2014;63(3):251-258.
Posted on: Wed, 29 Jan 2014 08:37:27 +0000