BioSmart Fact File 112.4 orbitbiotech orbitbiosmart Between B Cells and T Cells: Transcription Factor EBF1 Reminds Cells Who They Are Mature cells develop through a number of immature stages. During this process, they must remember the specialisation they are committed to. For immune system B cells, Rudolf Grosschedl of the Max Planck Institute of Immunobiology and Epigenetics and his team have discovered that the transcription factor EBF1 is crucial for B cells to remember who they are. When the researchers switched off the transcription factor, the cells lost their previous identity and developed into T cells. Unlike most other cell types, B cells have a characteristic footprint in their genetic makeup and this allowed the researchers to identify the origin of each individual cell.
Posted on: Thu, 25 Jul 2013 11:07:18 +0000
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