Bipolar Disord. 2008 Feb;10(1):111-3. Homicidal ideation with intent during a manic episode triggered by antidepressant medication in a man with brain injury. Dealberto MJ, Marino J, Bourgon L. Department of Psychiatry, Ottawa Hospital, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. [email protected] BACKGROUND: Mood disorders are more frequent after brain injury and both depressive and manic episodes are associated in these patients with an increased risk of aggression. Antidepressant medications are associated with a risk of manic induction. CASE REPORT: We describe a case of homicidal ideation with intent during the onset of a manic episode in a patient with prior brain injury on antidepressant medication at low dosage. The manic episode could have been secondary to brain injury and/or triggered by antidepressant medications. This case raises the possibility of the sensitizing role of brain injury for antidepressant-induced mania. CONCLUSIONS: Further studies are needed to assess the role of brain injury as a risk factor for antidepressant-induced mania. Physicians should be cautious when prescribing antidepressants to patients with prior brain injury and inform them and their relatives of the possibility of a switch into mania.
Posted on: Wed, 02 Jul 2014 20:56:00 +0000
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