Brugada Syndrome: Autosomal dominant inherited arrhythmic - TopicsExpress

Brugada Syndrome: Autosomal dominant inherited arrhythmic disorder characterized by mutation in sodium-channels Arrhythmic events are often observed at rest or while asleep, resulting in VF and SCD Diagnostic criteria consists of 2 parts: (1) ECG abnormalities (2) clinical characteristics A. ECG abnormalities: incomplete or complete RBBB in right precordial leads (V1-V2) w/ Type I coved-type ST segment elevation and negative T wave Type II saddle-back ST segment elevation followed by a positive or biphasic T wave Type III ST segment elevation without meeting criteria for type I or II variants B. Clinical characteristics: hx of VT/ VF, family hx of SCD or abnormal ECG, agonal respirations during sleep, or inducible VT/VF during EP study

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