CYP1A1 regulates breast cancer proliferation and survival...This - TopicsExpress

CYP1A1 regulates breast cancer proliferation and survival...This study supports the notion that CYP1A1 promotes breast cancer proliferation and survival... reduction of CYP1A1 levels is a potential strategy for breast cancer therapeutics. ncbi.nlm.nih.gov/pubmed/23576571 Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes...These results indicated that CBD and CBN showed CYP1 isoform-selective direct inhibition and that CBD was characterized as a potent mechanism-based inhibitor of human CYP1 enzymes, especially CYP1A1... CBD most potently inhibited the CYP1A1 activity. ncbi.nlm.nih.gov/pubmed/20117100

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