Cell 148, March 16, 2012 - Elsevier Leading Edge Review The Impact of the Gut Microbiota on Human Health: An Integrative View Jose C. Clemente, Luke K. Ursell, Laura Wegener Parfrey, and Rob Knight Department of Chemistry & Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA Howard Hughes Medical Institute, Boulder, CO 80309, USA *Correspondence: [email protected] DOI 10.1016/j.cell.2012.01.035 The human gut harborsdiverse microbesthat play afundamental role in thewell-being of their host. The constituents of the microbiota—bacteria, viruses, and eukaryotes—have been shown to interact with one another and with the host immune system in ways that influence the development ofdisease.Wereviewtheseinteractionsandsuggestthataholisticapproachtostudyingthemicro- biota that goes beyond characterization of community composition and encompasses dynamic interactions between all components of the microbiota and host tissue over time will be crucial for building predictive models for diagnosis and treatment of diseases linked to imbalances in our microbiota.
Posted on: Sat, 03 Jan 2015 14:24:46 +0000
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