Conclusions: A decrease in the CD57 lymphocyte subset may be an important marker of chronic LD. Changes in the CD57 subset may be useful to monitor the response to therapy in this disease. sciencedirect/science/article/pii/S0165247800003163 We conclude that chronic forms of Lyme borreliosis can evolve due to an aberrant innate proinflammatory response. onlinelibrary.wiley/doi/10.1111/j.1600-0463.2007.apm_538.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false The work presented here has helped to clarify the mechanisms by which B. burgdorferi and T. pallidum initiate innate and adaptive immune responses. Taken collectively, our data demonstrate that the difference in immunostimulatory capacity between B. burgdorferi and T. pallidum is a result of dramatically different levels of phagocytosis of these two organisms, not the relative abundance of surface-expressed lipoproteins per se as we previously proposed (69). Presumably, live B. burgdorferi displays at least one moiety on its surface, which T. pallidum lacks, that promotes recognition and phagocytosis by host cells. When the host counters this immune evasion strategy via the production of opsonic antibody, the efficiency of T. pallidum internalization is dramatically enhanced, leading to cellular and cytokine responses similar to those generated by B. burgdorferi. iai.asm.org/content/75/4/2046.full In summary, Marques et al. have provided questionable data about the CD3− CD57+ NK subset in an underpowered analysis of a heterogeneous group of patients, and their data are insufficient to reach a meaningful conclusion. As noted in our larger population-based study, which was supported by more recent immunologic evaluation (4), the CD3− C57+ NK subset appears to be a useful immunologic marker in patients with persistent Lyme disease symptoms. cvi.asm.org/content/16/11/1704.short ncbi.nlm.nih.gov/pmc/articles/PMC1782288/ onlinelibrary.wiley/doi/10.1111/j.1365-3083.2008.02191.x/full We describe 3 cases in which transmission of Borrelia burgdorferi, the spirochetal agent of Lyme disease, appears to have occurred in less than 24 h based on the degree of tick engorgement, clinical signs of acute infection, and immunologic evidence of acute Lyme disease sciencedirect/science/article/pii/S0732889311004159
Posted on: Thu, 13 Jun 2013 14:48:59 +0000