[DOI: 10.2174/1874357900903010001] The Evolution of Viruses in Multi-Host Fitness Landscapes, 2009; 3: Pp. 1-6 Santiago F. Elena, Patricia Agudelo-Romero and Jasna Lalic Published Date: (19 March, 2009) Provided that generalist viruses will have access to potentially unlimited hosts, the question is why most viruses specialize in few hosts. It has been suggested that selection should favor specialists because there are tradeoffs limiting the fitness of generalists in any of the alternative hosts or because evolution proceeds faster with narrower niches. Here we review experiments showing that virus adaptation to a specific host is often coupled with fitness losses in alternative ones. In most instances, mutations beneficial in one host are detrimental in another. This antagonistic pleiotropy should limit the range of adaptation and promote the evolution of specialization. However, when hosts fluctuate in time or space, selective pressures are different and generalist viruses may evolve as well. benthamscience/open/tovj/articles/V003/1TOVJ.pdf
Posted on: Tue, 11 Jun 2013 04:29:33 +0000