Diagnostic Implications of L1, p16, and Ki-67 Proteins and HPV DNA - TopicsExpress

Diagnostic Implications of L1, p16, and Ki-67 Proteins and HPV DNA in Low-grade Cervical Intraepithelial Neoplasia Gatta, Luisa Benerini; Berenzi, Angiola; Balzarini, Piera; Dessy, Enrico; Angiero, Francesca; Alessandri, Giulio; Gambino, Angela; Grigolato, Piergiovanni; Benetti, Anna International Journal of Gynecological Pathology. 30(6):597-604, November 2011. The expressions of p16, Ki-67, and L1 proteins and human papillomavirus DNA were investigated using polymerase chain reaction (HPV/PCR) and catalyzed signal-amplified colorimetric DNA in situ hybridization (CSAC/ISH) as potential molecular markers for the diagnosis and transforming potential of low cervical intraepithelial neoplasia (CIN1). Ki-67 and p16 protein expression increased linearly from control cases to more dysplastic cases (CIN1, CIN2, and CIN3), peaking in squamous cell carcinoma cases (P

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