Digoxin :: Digoxin has somewhat variable oral absorption; it can be given orally or intravenously. The peak effect after an intravenous (IV) dose occurs in 1.5—2 hours. the half-life (t1/2) of digoxin is approximately 1.5 days.The maintenance dose of digoxin is approximately 35% of the loading dose Digoxin produces a therapeutic effect (and its toxic effects disappear) more rapidly than digitoxin. However, because of a relatively rapid clearance, lack of compliance may diminish the therapeutic effects.Digoxin is eliminated by the renal route .the t1/2 is prolonged in individuals with impaired renal function. Digoxin dosage can be adjusted on the basis of creatinine clearance.
Posted on: Thu, 27 Jun 2013 21:14:56 +0000