Dr. Robert Austin, Professor of Physics, Princeton University. Friday, May 16th, 226 Weill Hall 4:30PM Talk Reception at 4:00PM, Drinks and hor doeuvres Title: The Physics of the Games Cancer Plays Abstract: Cancer is a complex condition with strong ecological elements, often consisting of stromal cells as well as cancer cells. I’ll talk about a microfluidic ecology which mimics tissue ecology under chemotherapy to visualize the dynamics of multiple myeloma and stromal cell interactions and the emergence of resistance. We model the observed spatial dynamics of emergent resistance using spatial evolutionary game theory, with (i) fitness as a function of population composition and drug concentration, and (ii) spatial coupling via diffusive migration and fitness-driven migration of the cells. Ill show that evolutionary game theory applied to two interacting cell populations can yield quantitative prediction of future densities of the two cell populations based on their fitness as a function of population composition. I believe that evolutionary game theory successfully predicts the future densities of strains of bone marrow stromal and cancer cells, and opens the possible clinical use of such analysis for predicting and controlling cancer progression.
Posted on: Thu, 15 May 2014 18:15:02 +0000
Trending Topics
Recently Viewed Topics
© 2015