Drug crosses blood-brain barrier, kills brain tumor cells An experimental drug being developed by scientists at the Ohio State University Comprehensive Cancer Center can cross the blood-brain barrier, making it a promising novel treatment for deadly brain tumors. OSU researchers conducted a laboratory and animal study with a nanovesicle drug called SapC-DOPS (saposin-C dioleoylphosphatidylserine) and found that the drug was effective at killing tumor cells and blocking the growth of tumor blood vessels in two brain tumor models. The nanovesicles--tiny, drug-carrying vehicles--fuse with tumor cells, causing them to self-destruct and die. The findings were published in a recent issue of the journal Molecular Therapy. The findings suggest that, with further development, the drug could be a potential treatment for glioblastoma, the most common and most aggressive type of brain tumor with an average survival rate of about 15 months. A combination of surgery followed by radiation therapy and chemotherapy may increase the chances of survival. Read more: Drug crosses blood-brain barrier, kills brain tumor cells - FierceBiotech Research fiercebiotechresearch/story/drug-crosses-blood-brain-barrier-kills-brain-tumor-cells/2013-07-23#ixzz2a2NtQzQO Subscribe at FierceBiotech Research
Posted on: Thu, 25 Jul 2013 06:49:49 +0000
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