Free Webinar: Multidisciplinary Investigation of the CFTR Ion Channel An insight on Ion Channel CFTR and its benefits Thursday, September 12, 2013 | 4:00 PM GMT During this multidisciplinary webinar our speakers will present data using several of the Molecular Devices platforms, including single channel voltage clamp data with our Axon™ Instruments line of electrophysiology products, and screening against the CFTR channel with the FLIPR®, and our automated electrophysiology platforms the IonWorks® Quattro™ and IonWorks® Barracuda®. The cystic fibrosis transmembrane conductance regulator (CFTR) is an ABC transporter-class ion channel that transports chloride and thiocyanate ions across epithelial cell membranes. CFTR channels are found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, reproductive tract, and skin. Mutations in this protein lead to the disease cystic fibrosis, characterised by chronic lung dysfunction, disability, and a reduced life expectancy. Important areas of research are being targeted to identify compounds that restore the function of the mutant forms of CFTR that are responsible for cystic fibrosis. Additionally inhibitors of CFTR have been identified for treating diarrhoeal disease. Diarrhoea, a disease of poverty and poor sanitation is estimated to kill over two million children each year in the developing world. The CFTR channel is an important target as it is the primary driver of secretion in cases of diarrhoea caused by enterotoxigenic bacteria. Indeed some of these molecules are now being evaluated in clinical trials. #Biofocus #universityofbristol #webinar #ionchannels info.moleculardevices/acton/form/2560/03b6:d-0009/0/index.htm
Posted on: Tue, 13 Aug 2013 15:34:22 +0000
Trending Topics
Recently Viewed Topics
© 2015