Germline mitochondrial DNA mutations aggravate ageing and can - TopicsExpress

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Ross et al. Nature September 2013 Mutations in mitochondrial DNA (mtDNA) accumulate at a higher rate than mutations in nuclear DNA, and although somatic mtDNA mutations are known to be involved in mammalian ageing, the role of germline mutations in this process is unclear: here germline-transmitted mtDNA mutations are shown to be associated with ageing and brain malformations, and maternally transmitted mtDNA mutations may thus influence both development and ageing. nature/nature/journal/v501/n7467/full/nature12474.html nature

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