. (Getty Images)AAPBritish-American researcher John OKeefe has won the Nobel Medicine Prize with a Norwegian couple, Edvard and May-Britt Moser, for discovering how the brain navigates.They earned the coveted prize for discovering a positioning system - aninner GPS - which enables us to orient ourselves in space, the jury said.The research has implications for Alzheimers and other diseases of the brain, it said.The discoveries of John OKeefe, May-Britt Moser and Edvard Moser have solved a problem that has occupied philosophers and scientists for centuries, it said.How does the brain create a map of the space surrounding us and how can we navigate our way through a complex environment?In 1971, OKeefe discovered the first component of the system, finding that in lab rats, specific cells in the hippocampus were stimulated when the animal was at a certain location in a room.Other nerve cells were activated when the rat was at other places, leading OKeefe to conclude that these placecells formed a map of the room.More than three decades later, in 2005, May-Britt and Edvard Moser discovered another piece of the invisible positioning system.They identified grid cells - nerve cells which generate a coordinated system, rather like longitude and latitude, andallow the brain to make precise positioning and pathfinding.Research into grid cells may give insights into howmemories are created - and explain why when we recall events, we so often have to picture the location in our minds.The jury pointed out that sufferers of Alzheimers disease often lose their way and cannot recognise the environment.Knowledge about the brains positioning system may, therefore, help us understand the mechanism underpinning the devastating spatial memory loss that affects people with this disease, it said.May-Britt Moser told the Nobel Foundation that shewas in shock, and that her husband didnt even know yet as he was on a plane to Munich.Part of their success comes from being a couple, she explained.We have the same vision, we love to understand andwe do that by talking to each other, talking to otherpeople and then try to address the questions we are interested in, the best way we can think of, she said.And to be able to discuss this when you get an idea on the spot instead of (having to) plan a meeting in one or two or three weeks - that makes a huge difference.The jury said the work had led to a paradigm shift in understanding how groupsof specialised cells work together in the brain.The question of place and navigation has occupied philosophers for centuries and was a central problemfor German thinker Immanuel Kant, it said.John OKeefe was born in 1939 while May-Britt Moser was born in 1963 and her husband Edvard Moser in 1962.The winners will share the prize sum of eight million Swedish kronor ($A1.19 million), with one half going to OKeefe.Last year the honour went to James Rothman, Randy Schekman and Thomas Suedhof, all of the United States, for their work on how the cell organises its transport system.In line with tradition, the laureates will receive their prize at a formal ceremonyin Stockholm on December10, the anniversary of prizefounder Alfred Nobels death in 1896.
Posted on: Mon, 06 Oct 2014 22:51:58 +0000
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