Glycolysis- 11 2,3-bisphosphoglycerate in erythrocytes The synthesis of 2,3-bisphosphoglycerate in erythrocytes is critical for controlling hemoglobin affinity for oxygen. Synthesis of 2,3-bisphosphoglycerate represents a major reaction pathway for the consumption of glucose in erythrocytes. When glucose is oxidized by this pathway the erythrocyte loses the ability to gain 2 moles of ATP from glycolytic oxidation of 1,3-BPG to 3-phosphoglycerate via the phosphoglycerate kinase reaction. 1,3-bisphosphoglycerate ----> 2,3- bisphosphoglycerate This reaction is catalyzed by enzyme bisphosphoglycerate mutase. 2,3-bisphosphoglycerate ------> 3-phosphoglycerate + Pi This reaction is catalyzed by 2,3-bisphosphoglycerate phosphatase. The process is not reversible under physiological conditions. 3-phosphoglycerate is an intermediate of glycolysis.
Posted on: Mon, 27 Oct 2014 08:44:07 +0000