Haematopoietic stem cells require a highly regulated protein synthesis rate Dr. Adrian Salics laboratory at Harvard Medical School chemically modified the antibiotic puromycin in a way that made it possible to visualize and quantify the amount of protein synthesized by individual cells within the body. Dr. Robert A.J. Signer, a postdoctoral research fellow in Dr. Morrisons laboratory and first author of the study published in Nature, realized that this reagent could be adapted to measure new protein synthesis by stem cells and other cells in the blood-forming system. What they came across was astonishing, Dr. Morrison said. The findings suggested that different types of blood cells produce vastly different amounts of protein per hour, and stem cells in particular synthesize much less protein than any other blood-forming cells.
Posted on: Mon, 10 Mar 2014 12:25:30 +0000
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