Here is the answer to this weeks #USMLE review question: Choice e is correct. Endometrioid adenocarcinoma is the most common form of endometrial carcinoma and forms well-differentiated, gland-forming tumors. Endometrial carcinoma is the most common genital cancer in developed countries and is the 4th most common cancer in women in the United States. The most common symptom is post-menopausal bleeding. Risk factors for endometrial cancer are associated with unopposed estrogen exposure, such as obesity, nulliparity and late-onset of menopause. Choice a is incorrect. This is consistent with clear-cell carcinoma. Although this is also a form of endometrial cancer, it comprises only 5 to 10 percent of cases of endometrial carcinoma. The characteristic clear cytoplasms is due to the presence of glycogen. Clear cell carcinoma is a more aggressive neoplasm that often presents at a more advanced stage than endometrioid adenocarcinoma.This condition is associated with female offsprings of mothers who have been exposed to the discontinued abortive agent known as diethylstilbestrol (DES). Choice b is incorrect. This is consistent with serous endometrial carcinoma. This cancer accounts for 1 to 5 percent of endometrial carcinomas and is marked by papillary architecture with marked nuclear atypia and often contains psammoma bodies. Like clear cell carcinoma, serous carcinoma is a more aggressive neoplasm that often presents at a more advanced stage. Choice c is incorrect. This is consistent with a mixed mullerian tumor. This form of uterine cancer has both epithelial and sarcomatous elements. It accounts for 2 to 5 percent of all tumors found in the body of the uterus and has similar risk factors as the other endometrial carcinomas. Choice d is incorrect. This is consistent with a leiomyosarcoma. It accounts for 5 to 10 percent of soft tissue sarcomas and is differentiated from benign leiomyomas by its high mitotic rate. Although commonly found in the uterus, it can also be seen in the GI tract in children.
Posted on: Thu, 10 Jul 2014 14:52:11 +0000
Trending Topics
Recently Viewed Topics
© 2015