How is it diagnosed? The diagnosis is suggested by the symptoms and results of blood tests such as a blood count, blood film (see above), renal function and markers of haemolysis. The activity of ADAMTS13 can be directly measured and is found to be reduced. The absolute plasma level of ADAMTS13 is reduced in the inherited form and the DNA mutations in the gene encoding the enzyme can be identified. The blood level of lactate dehydrogenase can be used as a measure of the extent of continueing red cell destruction, and the LDH level and platelet count are used to monitor the course of the condition. Other more common causes of an acute illness with low platelets (thrombocytopenia) must also be excluded.
Posted on: Mon, 18 Nov 2013 22:21:18 +0000
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