How many times you have to tell people MICES did not get the infections we got for decades in infectious vaccines? ncbi.nlm.nih.gov/pubmed/25009275 J Neurosci. 2014 Jul 9;34(28):9441-54. doi: 10.1523/JNEUROSCI.5314-13.2014. Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinsons disease-like models. Games D1, Valera E2, Spencer B2, Rockenstein E2, Mante M2, Adame A2, Patrick C2, Ubhi K2, Nuber S2, Sacayon P1, Zago W1, Seubert P1, Barbour R1, Schenk D1, Masliah E3. Mice were immunized with the new monoclonal antibodies 1H7, 5C1, or 5D12, all directed against the CT of α-syn. CT α-syn antibodies attenuated synaptic and axonal pathology, reduced the accumulation of CT-truncated α-syn (CT-α-syn) in axons, rescued the loss of tyrosine hydroxylase fibers in striatum, and improved motor and memory deficits.
Posted on: Mon, 14 Jul 2014 05:20:22 +0000
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