I think you are very familiar and some of you may have done it already: #icebucketchallenge that is to increase awareness of the #ALS neurodegeneration problem. How Does Protandim: Nrf2 Activator works with ALS and its medical studies relate to? SOD1 and DJ-1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegeneration. Abstract Neurodegenerative diseases share diverse pathological features and among these oxidative stress (OS) plays a leading role. Impaired activity and reduced expression of antioxidant proteins have been reported as common events in several aging-associated disorders. In this review paper, we first provide an overview of the involvement of reactive oxygen species- (ROS-) induced oxidative damage in Parkinsons disease (PD) and amyotrophic lateral sclerosis (ALS). Subsequently, we focus on DJ-1 and SOD1 proteins, which are involved in PD and ALS and also exert a prominent role in the interaction between redox homeostasis and neurodegeneration. Interestingly, recent studies demonstrated that DJ-1 and SOD1 are both tightly connected with Nrf2 protein, a transcriptional factor and master regulator of the expression of many antioxidant/detoxification genes. Nrf2 is emerging as a key neuroprotective protein in neurodegenerative diseases, since it helps neuronal cells to cope with toxic insults and OS. We herein summarize the recent literature providing a detailed picture of the promising therapeutic efficacy of Nrf2 natural and synthetic inducers as disease-modifying molecules for the treatment of neurodegenerative diseases. #icebuketchallenge and #ALS with #Nrf2 and #Protandim:NRf2 activator ncbi.nlm.nih.gov/pubmed/23983902 CLICK and SHARE: mylifevantage/greenpro/shop LIKE us on FB:facebook/cutoxidativestress
Posted on: Fri, 22 Aug 2014 07:29:19 +0000
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