ICU Roomより。 Q: 42 year old female with no significant past medical history except for hypertension, presented to ER with dizziness and palpitations. Initial rhythm showed runs of V.Tach. Only significant description given in history is recent episode of UTI (urinary tract infection) for which she was prescribed antibiotics by an urgent care physician. Which drug interaction is suspected? 質問：42歳の女性がめまいと動悸で救急外来を受診した。高血圧以外に特記すべき既往歴はない。心電図では心室頻拍が認められた。誘因として考えられるのは、休日診療所に細菌尿路感染症で受診し抗生物質を処方されたことぐらいである。どんな薬剤の関連が考えられるか？ Answer: Bactrim (Trimethoprim-sulfamethoxazole) and ACE-Inhibitor (ACE-I) Among patients treated with ACEIs or ARBs, the use of Bactrim is associated with a life threatening hyperkalemia, in comparison to other antibiotics. Alternate antibiotic therapy should be considered in such situation.
Posted on: Fri, 27 Jun 2014 23:20:43 +0000
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