ICU Roomより。 Q: What anti-seizure medicine may cause - TopicsExpress

ICU Roomより。 Q: What anti-seizure medicine may cause hyperammonemic encephalopathy, despite normal liver function, normal doses and normal serum levels? 質問：薬剤投与量は問題なく、血中濃度が正常かつ肝機能が正常な患者でも、高アンモニア血症による脳症を起こす可能性がある抗けいれん薬は何か？ Answer: Valproic acid (VPA) The use of valproic acid (VPA) (Depakote) frequently causes hyperammonemia. Usually it is clinically not significant but in some people, hyperammonemia may be clinically evident as encephalopathy, which may become life threatening. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, with normal doses and normal serum levels.

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