INTRODUCTION OF COLLAGEN – Surgeons who treat Burns & Trauma etc. face a real challenge in closing the raw areas due to non-availability of adequate Donor areas. It is for this reason, Biological Skin Substitutes have been evolved which come very handy for the Surgeons to manage the raw areas efficiently and to reduce the Mortality & Morbidity associated with Burns and Wound. Among the Biological Skin Substitutes Collagen Dressings have been widely established as an effective dressing for Burns and Wounds because of the easy availability in Sterile usage conditions in convenient sizes. COLLAGEN – Collagen is an extra cellular matrix protein playing a major role in connective tissue. It is the most abundant protein in humans and performs multiple functions. In fish, the largest concentration of Collagen is found in the skeleton, fins, skin and air bladder. Collagen is a bio-material and its role in Wound managementis a well-documented subject. Collagen encourages wound healing through the deposition and organization of freshly formed fibres and granulation tissue in the wound bed & thus creating a very conducive environment to wound healing. ROLE OF COLLAGEN IN WOUND HEALING – 1. Stops bleeding. 2. Helps in wound debridement by attracting Monocytes. 3. Provide a Matrix for Tissue and Vascular growth. 4. Attracts Fibroblasts and helps in directed Migration of cells. 5. Binds with Fibronectin, which promotes cell binding. 6. Supports growth, differentiation and migration of Keratinocytes. 7. Helps in deposition of oriented and organized fibres, which increases the integrity of the tissue. Collagen is a natural substrate for cellular attachment, growth and differentiation, and has been widely established as an effective dressing for burns and wounds. • Collagen reduces wound pH • A lowered pH reduces bacterial load leading to a reduction in infection & reduction of fluid loss • Acts as a biodegradable haemostat • Facilitates the normal healing process • Non-toxic, non-allergenic, non-immunogenic, non-pyrogenic • Transforms wounds from inflammation phase to remodeling phase • Acts as a natural stimulant for autolytic debridement • Collagen acts as scaffold for tissue regeneration
Posted on: Sat, 22 Jun 2013 09:23:48 +0000
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