In a second set of experiments (protocol b), we studied whether the effects of DCA were sustained for longer periods of time and whether DCA would have a similar effect in more advanced tumors. We followed three groups of rats (n = 6/group) for 12 weeks: an untreated control group, a prevention group (rats given DCA at the time of tumor cell injection), and a reversal group where rats were given DCA at week 10 for 2 weeks. As in protocol a, at all times rats in the prevention group had significantly smaller tumors compared to the untreated controls; DCA at week 10 inhibited tumor growth immediately, with a significant decrease even after 1 week of treatment. DCA therapy did not have any toxic effects, as measured by several blood tests (Figure 8D; also see McMurtry et al., 2004).
Posted on: Tue, 30 Sep 2014 04:04:16 +0000
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