In the past, biologic products have served as vectors for viral diseases. Examples include the contamination of yellow fever vaccine with hepatitis B virus in the 1940s (because a human-derived excipient contained hepatitis B virus), contamination of early polio and adenovirus vaccines with simian virus 40 in the late 1950s and early 1960s, contamination of blood products with hepatitis viruses and HIV, and contamination of dura mater grafts with the Creutzfeldt-Jakob disease agent. In these examples, either human or animal materials used in production usually caused the contamination.wwwnc.cdc.gov/eid/article/7/7/01-7735_article.htm
Posted on: Sat, 20 Jul 2013 22:34:59 +0000
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