Interesting: Nitrous oxide (N2O) for treatment-resistant major depression: A proof-of-concept trial Biological Psychiatry, 01/04/2015 Nagele P, et al. – This proof–of–concept trial demonstrated that nitrous oxide has rapid and marked antidepressant effects in patients with treatment–resistant depression. Methods In this blinded, placebo-controlled crossover trial 20 TRD patients were randomized to a 1-hour inhalation of 50% nitrous oxide/50% oxygen or 50% nitrogen/50% oxygen (placebo control). Primary endpoint was the change on HDRS-21 24 hours after treatment. Results Mean duration of nitrous oxide treatment was 55.6 ± 2.5 (SD) minutes at a median inspiratory concentration of 44% (37 – 45%, IQR). In two patients nitrous oxide treatment was briefly interrupted and in three discontinued. Depressive symptoms improved significantly at 2 hours and 24 hours after receiving nitrous oxide compared to placebo (mean HDRS-21difference at 2 hours: -4.8 points, 95% CI -1.8 to – 7.8 points, p= 0.002; at 24 hours: -5.5 points, 95% CI -2.5 to -8.5 points, p
Posted on: Sun, 04 Jan 2015 15:05:28 +0000
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