Intriguing life-extension research out of UCLA, shows that up-regulating genes encoding the signaling protein AMPK extended lifespan in the fruit fly by 30%. Its tempting to discount this for two reasons. First, this is a very simple organism, while humans are genetically far more complex. Second, of course is that genetic manipulation is easy in fruit flies and has yet to be successfully conducted in humans. Weve known the exact location of the genetic defect for most inherited diseases, yet no patient has been cured. At the same time, however, this is exciting news because we know how to up-regulate AMPK without any genetic tinkering. Go to the index of The Metabolic Makeover, and youll see that AMPK is discussed 17 times. In Chapter 8, Natalie and I list eight metabolic modifiers that have been shown to increase tissue levels of this metabolic master switch. Its All About Energy after all. singularityhub/2014/09/11/longevity-gene-in-fruit-flies-hints-at-coming-genetic-discoveries-to-slow-aging/
Posted on: Fri, 12 Sep 2014 17:30:25 +0000
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