Long-term use of mobile phone and its association with glioma: a systematic review and meta-analysis Gong X, Wu J, Mao Y, Zhou L. [Long-term use of mobile phone and its association with glioma: a systematic review and meta-analysis]. Zhonghua Yi Xue Za Zhi. 2014 Oct;94(39):3102-6. [Article in Chinese] Abstract OBJECTIVE: The hypothesis that cell phone induces brain tumor has become a target of much controversy for several decades and is still a matter of debate even now. We aim to make a systematic review and meta-analysis based on published studies on glioma to identify current evidences for evaluating mobile phones and glioma risk, especially on long-term use of mobile phones. METHODS: The study was conducted according to the Cochrane systematic review methods and reported according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement according to a prospective research protocol accessed via crd.york.ac.uk/prospero. The software RevMan 5 was used for statistic analysis. Latency and lateralization were used for the examining the dose-response relationship. RESULTS: Overall evidence suggested the increased risk of glioma among long-term ipsilateral users of mobile phone with an odds ratio (OR) of 1.46 [1.12, 1.92] based on meta-analysis. Especially, for low-grade glioma, long-term use yielded an OR value of 2.27 [1.81, 2.85]. CONCLUSION: The evidence is currently insufficient on this issue, especially on long-term use of mobile phone. Neither a definite answer nor a clear explanation may be offered for the relationship. And larger prospective trials are warranted. 1.usa.gov/1HBc4wm
Posted on: Tue, 06 Jan 2015 02:14:03 +0000
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