Low Concentrations Of Testosterone Predict Acute Myocardial Infarction In Men With Type 2 Diabetes Mellitus - Low testosterone concentrations in men have been associated to diabetes, hypertension and CVD-mortality and all cause mortality. We aimed to investigate the associations between endogenous testosterone and acute myocardial infarction (AMI) in men with type 2 diabetes mellitus (T2DM). The study was conducted in 1109 subjects >/= 40 years of age who participated in a population survey conducted in a rural area of southern Sweden with baseline examinations in 1993-94. Information about smoking habits and physical activities was assembled using validated questionnaires. The prevalence of T2DM at baseline was 10% in men and 7,5% in women. During follow-up of 13,8y ± 5,5y, there were 89 AMI events in men (74 in diabetics and 15 in non diabetics) and 72 in women (61 in non diabetics and 11 in diabetics). In the age adjusted Cox models there was a significant inverse association between AMI morbidity and testosterone in men with T2DM. Low concentrations of testosterone predicted AMI in diabetic men in this cohort independent of other risk factors. Whether testosterone replacement therapy could reduce the risk of AMI in men with T2DM remains to be investigated.
Posted on: Wed, 25 Sep 2013 11:42:31 +0000
Trending Topics
Recently Viewed Topics
© 2015