Markers of MI .................... Cardiac Enzymes - CPK-MB: This cardiac isoenzyme starts rising within 4-6 hrs after development of acute MI, peaks during the 2nd day and disappears in 2-3 days. Other causes of total CK elevation: - Skeletal disease - Polymyositis, Muscle dystrophy, Myopathies - Electrical cardioversion - Skeletal muscle damage - trauma, convulsions, immobilization - Hypothyroidism - Stroke - Surgery AST: Starts rising on the 1st day, peaks in 2-3 days and disappears by 3rd day. LDH: Starts rising by second day, peaks around 3-4 days and disappears in 10 days. Myoglobin: It is increased within 2 hrs of onset of symptoms and remains increased for at least 7-12 hrs. Normal level is 20-100 ug / L. Troponin T: Cardiac troponin T is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. Troponin T and I reach a reliable diagnostic level in plasma by 12-16 hrs, maximal activity by 24-32 hrs, return to normal in 10-12 days. - Troponin I : 0-0.4 ng / ml - Troponin T : 0-0.1 ng / ml Cardiac troponins are detected in the serum by using monoclonal antibodies. These antibodies have negligible cross reactivity to skeletal muscle. Cardiac troponins I and T start to rise within 3-4 hours after myocardal infraction and remain raised for 4-10 days. Ref: R Alagappan , Manual Of Practical Medicine, 3rd Edition, Page 175,176.
Posted on: Mon, 01 Jul 2013 09:04:30 +0000
Trending Topics
Recently Viewed Topics
© 2015