Melasma --Pathogenesis of melasma (chloasma) (pregnancy mask) remains unknown. Treatment which is effective on the epidermal component of the pigmentation acts by the following mechanisms: inhibition of melanin synthesis, blockage of melanosome transker from melanocytes and keratinocytes (niacinamide). Solar eviction and photoprotection are a crucial element in the treatments. The gold standard in the treatment of melasma is hydroquinone which is an inhibitor of tyrosinase. However it is toxic to pigment cells (melanocytes) (phenolic molecule). May even cause Rebound repigmentation................................................................................................................................................................................................................................................................................................................................................................... Another phenolic and toxic molecule is N-acetyl-4-S-cysteaminylphenol. Recently a metabolite of the latter called cysteamine mercaptoethylamine has re-emerged. It is a thiolic, non-melanotoxic compound, which has recently become useable thanks to a new toxicology stabilizing it and reducing the strong smell, which was user unfriendly. Other non-toxic compounds include: kojic acid which is produced by a fungus called Arpergilline oryzae. Vitamin C, azelaic acid, tretinoin, liquirtan combination treatments (hydroquinone, steroids, tretinoin
Posted on: Thu, 25 Dec 2014 12:04:54 +0000
Trending Topics
Recently Viewed Topics
© 2015