Melatonin in GIT was shown to be generated in about 500 times larger amounts than it is produced in pineal gland. Role of melatonin in upper gastrointestinal tract. ncbi.nlm.nih.gov/pubmed/18212399 Melatonin membrane receptors in peripheral tissues: Distribution and functions. ncbi.nlm.nih.gov/pmc/articles/PMC3288509/ The concentrations of melatonin in the GIT are 10-100x higher than in the plasma and the total amount of melatonin in the GIT is around 400x higher than the amount of melatonin in the pineal gland. Thirty four years since the discovery of gastrointestinal melatonin. ncbi.nlm.nih.gov/pubmed/18812627/ Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food. ncbi.nlm.nih.gov/pubmed/8989725 Distribution, function and physiological role of melatonin in the lower gut. ncbi.nlm.nih.gov/pmc/articles/PMC3198018/ Simultaneous measurement of serotonin and melatonin from the intestine of old mice: the effects of daily melatonin supplementation. ncbi.nlm.nih.gov/pubmed/20374441/ The role of serotonin and melatonin in gastrointestinal physiology: ontogeny, regulation of food intake, and mutual serotonin-melatonin feedback. ncbi.nlm.nih.gov/pubmed/8014829/ The effect of food deprivation on brain and gastrointestinal tissue levels of tryptophan, serotonin, 5-hydroxyindoleacetic acid, and melatonin. ncbi.nlm.nih.gov/pubmed/1373446 Long-term melatonin administration attenuates low-LET gamma-radiation-induced lymphatic tissue injury during the reproductively active and inactive phases of Indian palm squirrels (Funambulus pennanti). ncbi.nlm.nih.gov/pubmed/20139262
Posted on: Wed, 24 Jul 2013 15:43:49 +0000
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