Metformin and the birth control pill both lead to B-12 deficiency. - TopicsExpress

Metformin and the birth control pill both lead to B-12 deficiency. To make matters more complicated, about 50% of the population is estimated to have at least one mutation at the MTHFR gene and 10% has two mutations, meaning theyre less able to methylate B12 or convert cyanocobalamin to methylcobalamin. Read more about MTHFR here - pcosdiva/2014/05/mthfr-what-is-it-and-how-can-this-effect-your-fertility/ This leaves so many women with PCOS severely deficient in Vitamin B-12.

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