Molecular change that occurs in the brain when we learn and remember! Published in Nature Neuroscience, the research shows that learning stimulates our brain cells in a manner that causes a small fatty acid to attach to delta-catenin, a protein in the brain. This biochemical modification is essential in producing the changes in brain cell connectivity associated with learning. This discovery gives us a much better understanding of the tools our brains use to learn and remember, and provides insight into how these processes become disrupted in neurological diseases, says co-author Shernaz Bamji, an associate professor in UBCs Life Sciences Institute. It may also provide an explanation for some mental disabilities. People born without the gene have a severe form of mental retardation called Cri-du-chat syndrome, a rare genetic disorder named for the high-pitched cat-like cry of affected infants. Disruption of the delta-catenin gene has also been observed in some patients with schizophrenia. Brain activity can change both the structure of this protein, as well as its function, When we introduced a mutation that blocked the biochemical modification that occurs in healthy subjects, we abolished the structural changes in brains cells that are known to be important for memory formation. authors claim.
Posted on: Fri, 07 Mar 2014 05:36:02 +0000