Montelukast (Singulair) and Drug-Induced Liver Injury - TopicsExpress

Montelukast (Singulair) and Drug-Induced Liver Injury - Mechanism of Liver Injury The cause of hepatotoxicity from montelukast is not known, but the rare incidence, absence of immunoallergic features and long latency period suggest that it is not due to hypersensitivity but rather to altered metabolism. Montelukast is metabolized by the cytochrome P450 system (CYP3A4 and CYP2C9) and hepatotoxicity may be caused by formation of toxic intermediates. livertox.nih.gov/Montelukast.htm

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