More obsession with graded exercise from Klimas and co and once again no control group.Excercise itself causes changes in cytokine production and a whole host of other neuroendocrine and immune changes. The patients with Fatigue and a minimum of four minor symptoms could have suffered from just about anything or nothing at all Brain Behav Immun. 2013 Feb;28:159-69. doi: 10.1016/j.bbi.2012.11.007. Epub 2012 Nov 29. Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis. Broderick G, Ben-Hamo R, Vashishtha S, Efroni S, Nathanson L, Barnes Z, Fletcher MA, Klimas N. Source Department of Medicine, University of Alberta, Edmonton, Canada. [email protected] Abstract Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating illness presenting with a complex constellation of immune, endocrine and neurological symptoms. Here we compared male GWI (n=20) with healthy veterans (n=22) and subjects with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) (n=7). Blood was drawn during a Graded eXercise Test (GXT) prior to exercise, at peak effort (VO2 max) and 4-h post exercise. Affymetrix HG U133 plus 2.0 microarray gene expression profiling in peripheral blood mononuclear cells (PBMCs) was used to estimate activation of over 500 documented pathways. This was cast against ELISA-based measurement of 16 cytokines in plasma and flow cytometric assessment of lymphocyte populations and cytotoxicity. A 2-way ANOVA corrected for multiple comparisons (q statistic
Posted on: Fri, 29 Nov 2013 10:07:17 +0000
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