More pain; less gain bit.ly/1s7aOKe Chronic pain is not only extremely disturbing and unpleasant; it can also make people depressed and demotivated. What causes these effects? Schwartz et al. discovered that chronic pain causes changes in the way a neuropeptide called galanin affects certain neurons in a brain region called the nucleus accumbens. Galanin influences a variety of behaviors, including feeding and certain aspects of pain. In this case, it depresses synaptic transmission at specific excitatory synapses. It does so, in part, by changing the ratio of subunits of an important receptor protein.
Posted on: Thu, 07 Aug 2014 16:10:28 +0000
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