Most people know my cousin Dr. Maqsudul Alam who recently passed away as the scientist who sequenced genome for jute, papaya, rubber and fungus. But few knows that he had invented many other things. Among them was a substitute for blood or artificial blood. Couple of years back he had shared with me his patent for blood substitute known as Heme proteins. He invented it in 1999. This is public information so I am not sharing anything personal or private. He was a genius. Heme proteins hemAT-Hs and hemAT-Bs and their use in medicine and microsensors (Dec 06, 1999 - University of Hawaii) The present invention provides an isolated archael and bacterial heme binding protein which reversibly binds oxygen with a low affinity. The heme binding protein may be utilized as a blood substitute. The invention also provides a method for controlled storage of oxygen by contacting a bacterial heme binding protein with oxygen allowing the protein to bind and store oxygen. The also provides methods to sense gaseous ligands using the heme binding protein. In other embodiments, the invention provides chimeric proteins having a heme-binding domain of an isolated heme binding archael bacterial protein and a heterologous signaling domain. patents.justia/patent/7129329
Posted on: Wed, 24 Dec 2014 19:44:30 +0000