Night Shift Work Causally Linked to an Increase in Breast Cancer ift.tt/1kagNtM Working at night increases the risk of breast cancer according to a recent study. Objectives The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors. Methods GENICA (Gene–ENvironment Interaction and breast CAncer) is a population-based case–control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders. Results ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were “ever employed” in shift work including night shifts for ≥1 year. In total, “ever shift work” and “ever night work” were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22–18.36]. Conclusions Our case–control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms The report: Rabstein S, Harth V, Pesch B, Pallapies D, Lotz A, Justenhoven C, Baisch C,Schiffermann M, Haas S, Fischer H-P, Heinze E, Pierl C, Brauch H, Hamann U, Ko Y,Brüning T, Night work and breast cancer estrogen receptor status – results from the German GENICA study, Scand J Work Environ Health 2013;39(5):448-455 doi:10.5271/sjweh.3360, 2010;36(2):163-179 2010;36(2):134-141 Read more ablout breast cancer and workers compensation: Workers Compensation: Breast Cancer Risk Doubles With ... Jul 02, 2013 Objectives Long-term night work has been suggested as a risk factor for breast cancer; however, additional studies with more comprehensive methods of exposure assessment to capture the diversity of shift patterns are ... ift.tt/RVUwFt Breast Cancer Linked to Workers Exposure at Semiconductor Factory Dec 15, 2012 A semiconductor plant worker, who had been exposed to solvents and radiation while working 5 years at a semiconductor factory in South Korea has been held to have suffered an compensable disease related to her ... ift.tt/RVUwFt Workers Compensation: Breast Cancer Presumed Occupational ... Mar 18, 2011 Fire fighters in Canada are supporting legislation that would establish a legal presumption that breast cancer is an occupationally related illness. The legislation also creates a presumption that 3 other cancers (skin, prostate ... ift.tt/RVUwFt Breast Cancer and the Environment: A Life Course Approach Dec 05, 2012 Breast Cancer and the Environment: A Life Course Approach - Institute of Medicine: With more than 230,000 new cases of breast cancer expected to be diagnosed in the United States in 2011, many wonder about the role ... ift.tt/RVUwFt Found on
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